Center for Enzyme Research in Health and Disease


As a protein-based substance, enzymes are critical for life processes. Every step of metabolism is controlled by enzymes. However, dysregulated enzyme activity can lead to disease states and pathophysiology condition, such as those found in metabolic disorders, Alzheimer’s disease, hyperpigmentation disorders, etc. Enzymes have become attractive drug target to cure these diseases. Enzymes research may also focus on enzyme therapy and enzymes as biomarkers. Our center is envisioning to do research on the inhibitors of medicinal relevant enzymes, enzyme therapy, and enzyme biomarker.

Tim Riset

  • Prof. Dr. Kris Herawan Timotius (chair person)
  • Dra. Adelina Simamora MS, M.Sc (Pharm) (vice chair person)
  • Ika Rahayu M.Sc (member)
  • Adit Widodo Santoso S.Si (member)


  1. Timotius, K. H. (2021). "Health Benefits of Edible Leave of Premna serratifolia L." HSOA Journal of Food Science and Nutrition 7(122): 1-5.
  2. Simamora A, Santoso AW, Timotius KH. Bioactive compounds and bioactivity studies of ethanol extracts from Pereskia bleo Kunth. Thai Journal of Pharmaceutical Sciences. 2021; 45 (4).
  3. Tjajaindra A, Sari AK, Simamora A, Timotius KH. The stem infusate and ethanol extract of Physalis angulata inhibitory activities against a-glucosidase and xanthine oxidase. Molecular and Cellular Biomedical Sciences. 2021; 5 (3): 115-20.
  4. Bustamam N, Simamora A. A mechanistic review of plumbagin effects against diabetes and obesity. Pharmaceutical Sciences Asia. 2021; 48 (6): 498-505.
  5. Simamora A, Santoso AW, Rahayu I, Timotius KH. Enzyme inhibitory, antioxidant, and antibacterial activities of ethanol fruit extract of Muntingia calabura Linn. Journal of Herbmed Pharmacology. 2020; 9 (4): 346-54.
  6. Simamora A, Santoso AW, Timotius KH, Rahayu I. Antioxidant activity, enzyme inhibition potentials, and phytochemical profiling of Premna serratifolia L. Leaf extracts. Int J Food Scie. 2020; 2020.
  7. Niwele F, Sitepu PS, Simamora A, Timotius KH, Santoso AW. Current Research in Nutrition and Food Science. Nutritional Enzymes Inhibitory Activities of Fruit Juice and Fruit Pulp Extract of Muntingia Calabura L. 2020; 8 (3): 1001-12.
  8. Kurniawan H, Dacamis ES, Simamora A, Tobing PSDL, Hanapiah A, Santoso AW. Antioxidant, Antidiabetic, and Anti-obesity Potential of Ipomoea reptans Poir Leaves. Borneo J Pharm. 2020; 3 (4): 216-26.
  9. Santoso AW, Simamora A, Timotius KH. Chromatographic (TLC) Fingerprinting, Antioxidant, α-Glucosidase, and Lipase Inhibitory Activities of Ethanol Extract of Muntingia calabura L. Fruits. Educational Research (IJMCER). 2020; 2 (4): 145-51.
  10. Natasha A, Timotius KH. The Biofilm Eradication Using Gentamicin and Anticoagulants as Catheter-Related Infection Prophylaxis in Hemodialysis Patients: A Systematic Review. Microbiology Biotechnology Letters. 2019; 47 (2): 173-82.
  11. Limanto A, Simamora A, Santoso AW, Timotius KH. Antioxidant, α-glucosidase inhibitory activity and molecular docking study of gallic acid, quercetin and rutin: a comparative study. Molecular and Cellular Biomedical Sciences. 2019; 3 (2): 67-74.
  12. Simamora A, Santoso AW, Timotius KH. α-Glucosidase inhibitory effect of fermented fruit juice of Morinda citrifolia L and combination effect with acarbose. Current Research in Nutrition and Food Science. 2019; 7 (1): 218-26.
  13. Simamora A, Timotius KH, Santoso AW. Antidiabetic, antibacterial and antioxidant activities of different extracts from Brucea javanica (L.) Merr seeds. Pharmacogn J. 2019; 11 (3).
  14. Timotius KH, Simamora A, Santoso AW. Chemical Characteristics and In Vitro Antidiabetic and Antioxidant Activities of Premna serratifolia L. Leaf Infusion and Decoction. Pharmacog J. 2018; 10 (6): 1114-8.
  15. Simamora A, Paramita L, Mohamad Hamid NAB, Santoso AW, Timotius KH. In vitro antidiabetic and antioxidant activities of aqueous extract from the leaves and fruit of Psidium guajava L. Indones Biomed J. 2018; 10 (2): 156-64.
  16. Simamora A, Santoso AW, Timotius KH. Bioactivities of methanol and ethyl acetate mace extracts of Myristica fragrans Houtt. Pharmacognosy Communications. 2018; 8 (3): 103-7.
  17. Steven M, Santoso AW, Rumiati F, Timotius KH. Antioxidant Activity of Methanol Extract from Several Indonesian Green Teas. Jurnal Kedokteran YARSI. 2018; 26 (1): 018-26.



Center for Enzyme Research in Health and Disease

Universitas Kristen Krida Wacana