Center for Enzyme Research in Health and Disease

Deskripsi

As a protein-based substance, enzymes are critical for life processes. Every step of metabolism is controlled by enzymes. However, dysregulated enzyme activity can lead to disease states and pathophysiology condition, such as those found in metabolic disorders, Alzheimer’s disease, hyperpigmentation disorders, etc. Enzymes have become attractive drug target to cure these diseases. Enzymes research may also focus on enzyme therapy and enzymes as biomarkers. Our center is envisioning to do research on the inhibitors of medicinal relevant enzymes, enzyme therapy, and enzyme biomarker.

Tim Riset

  • Prof. Dr. Kris Herawan Timotius (chair person)
  • Dra. Adelina Simamora MS, M.Sc (Pharm) (vice chair person)
  • Ika Rahayu M.Sc (member)
  • Adit Widodo Santoso S.Si (member)

Publikasi

  • Adelina Simamora, Adit Widodo Santoso, Kris Herawan Timotius 2017 Bioactivities of Methanol and Ethyl Acetate Mace Extracts of Myristica fragrans Houtt International Symposium on Natural Medicine (ISNM) 2017 Bogor Agriculture University (IPB)
  • Adelina Simamora, Michael Steven, Adit Widodo Santoso, Flora Rumiati, Kris Herawan Timotius 2018, Antioxidant Activity of Methanol Extract from Several Indonesian Green Teas, YARSI Medical Journal Vol 26, Issue 1, Page 018-026 http://dx.doi.org/10.33476/jky.v26i1   SINTA, Google Scholar, ISJD

  • Adelina Simamora, Lusia Paramita, Nur Azreen Binti Mohamad Hamid, Adit Widodo Santoso, Kris Herawan Timotius 2018, In Vitro Antidiabetic
    and Antioxidant Activities of Aqueous Extract from the Leave and Fruit of Psidium guajava L, Indonesia Biomedical Journal Vol 10, Issue 2, Page 156-64 Vol 10, Issue 2, Page 156-64 https://doi.org/10.18585/inabj.v10i2.402  Scopus Q4, Clarivate analytics, DOAJ, Thompson Reuters,SINTA, ISJD, dll.
  • Adelina Simamora, Adit Widodo Santoso, Kris Herawan Timotius 2018 Bioactivities of Methanol and Ethyl Acetate Mace Extracts of Myristica fragrans Houtt Pharmacognosy Communication Vol 8, Issue 3, Page 103-107. DOI:10.5530/pc.2018.3.22 Index Copernics, CABI, ProQuest, EBSCO Host EBSCO Google Scholar, dll
  • Kris Herawan Timotius, Adelina Simamora, Adit Widodo Santoso 2018, Chemical Characteristics and In vitro Antidiabetic and Antioxidant Activities of Premna serratifolia L. Leaf Infusion and Decoction Pharmacognosy Journal Vol 10, Issue 6, Page 1114-1118. DOI:10.5530/pj.2018.6.189 Scopus Q3, ProQuest,  EBSCO Host Google Scholar, dll.
  • Adit Widodo Santoso, Adelina Simamora, Kris Herawan Timotius 2018 Bioactivities of Water Extract and Essential Oil from the Mace of Myristica fragrans Hout Yarsi Medical Journal Vol 26, No 2 (2018) http://dx.doi.org/10.33476/jky.v26i2   Google Scholar, SINTA, ISJD
  • Adelina Simamora, Kris Herawan Timotius, Adit Widodo Santoso Januari-Februari, 2019, Antidiabetic, Antibacterial and Antioxidant Activities of Different Extracts from Brucea javanica (L.) Merr Seeds Pharmacognosy Journal Vol 11, Issue : 3, Hal: 479-485. DOI:10.5530/pj.2019.11.76 Scopus Q3 ProQuest, EBSCO, Host Google Scholar, dll.

  • Agus Limanto; Adelina Simamora, Adit widodo Santoso, Kris Herawan Timotius 2019, Antioxidant, a-Glucosidase Inhibitory activity and Molecular Docking Study of Gallic acid, Quercetin and Rutin: A Comparative Study Molecular Cell and Biomedical Sciences Vol 3 No 2 (2019) https://cellbiopharm.com/ojs/index.php/MCBS/article/view/60   SINTA, Index Copernicus    SINTA, Index Copernicus DOAJ.

  • Adelina Simamora, Adit Widodo Santoso and Kris Herawan Timotius April, 2019, α-Glucosidase Inhibitory Effect of Fermented Fruit Juice of Morinda Citrifolia L and Combination Effect with Acarbose,Current Research in Nutrition and Food Science, Vol. 07, Issue 1 2019, Page. 218-226 http://dx.doi.org/10.12944/CRNFSJ.7.1.21 Scopus, Q3, Clarivate Analytics, EBSCO, ProQuest, dll.

  • Augustine Natasha and Kris Herawan Timotius June, 2019, The Biofilm Eradication using Gentamicin and Anticoagolants as Catheter-related Infection Prophylaxis in Hemodialysis Patients: A Systematic Review, Miocrobiology and Biotechnology Letters, 47(2)173-182 http://dx.doi.org/ 10.4014/mbl.1808.08013 
  • Wong H.Wijaya, Kris H.Timotius and Jonathan K. Wijaya Submitted 2020, Extracellular Lipase of Malassezia as Anti Dandruff Drug Target: a Review Systematic Review in Pharmacy
  • Kris H.Timotius, Augustine Natasha and Wong H.Wijaya Submitted 2019, Treatment Challenges in Biofilm-related Disease; A Review, Journal of Applied Microbiology
  • Adelina Simamora, Adit W.Santosa, Ika Rahayu, Kris H.Timotius Accepted, Antioxidant and bioactivity of ethanol Extract from Muntingia callabura leave Journal of HerbMed Pharmacology, Scopus Q3.
  • Adelina Simamora, Adit W.Santosa, Ika Rahayu, Kris H.Timotius Submitted, Antioxidant Activity, Enzymes Inhibition Potentials, and Phytochemical Profiling of Premna serratifolia L Leaf Extracts,International Journal of Food Science,Scopus Q2.
  • Florensia Niwele, Putri Sitopu, Adelina Simamora, Kris H Timotius, Adit W. Santoso, Submited, Nutritional Enzymes Inhibitory Activities of Fruit Juice and Fruit Pulp Extract of Muntingia calabura L., Current Research in Nutrition and Food Science, Scopus Q3.
  • Kris H.Timotius and Augustine Natasha Writing, Enzyme treatment for biofilm-relate disease 
  • Ika Rahayu, Pamela, Kris H.Timotius Submitted, Synergistic effect of aqueous extract of three different leaves
  • Kris H.Timotius, Writing, The role of intracellular life of Burkholderia in its biofilm formation
  • Wong Hendra Wijaya and Kris H.Timotius Writing, The molecular mechanisms of synthetic drugs on melanogenesis
  • Wong Hendra Wijaya and Kris H.Timotius Writing, Herbal medicine for melanogenesis 
  • Ika Rahayu and Kris H.Timotius, Writing, DNA damage protection assay for herbal materials
  • Wong Hendra Wijaya, Ika Rahayu, and Kris H.Timotius, Experiment, Lipase of Malassezia 
  • Augustine Natasha and Kris H.Timotius, Writing, Biofilm in chronic lung infectious disease
  • Kris H.Timotius, Writing, The fatty acids composition and antibacterial activity of tempe oil and 

 

Kontak

Center for Enzyme Research in Health and Disease

Universitas Kristen Krida Wacana
  Cerih@ukrida.ac.id